Uji Efektivitas Ekstrak Etanol Herba Krokot (Portulaca Oleracea L) pada Mencit Putih (Mus Musculus) dengan Induksi Asam Asetat

Marissa Aulia; Muhammad Walid

doi:10.61132/obat.v3i2.1119

Authors

Marissa Aulia Universitas Pekalongan
Muhammad Walid Universitas Pekalongan

DOI:

https://doi.org/10.61132/obat.v3i2.1119

Keywords:

Analgesic, Purslane, plant, Acetic, Acid

Abstract

Pain is the body's response to tissue damage that is often addressed using analgesic compounds. Purslane plants (Portulaca oleracea L) are known to contain flavonoids, saponins, tannins, and alkaloids that have potential as analgesics. This study aims to test the analgesic effectiveness of purslane ethanol extract by writhing test method using white mice (Mus musculus) induced by 1% acetic acid. A total of 15 mice were divided into 5 treatment groups, namely negative control, positive control (paracetamol), and three groups with doses of purslane extract 200 mg/kgBB, 400 mg/kgBB, and 800 mg/kgBB. The number of writhes was observed every 15 minutes for 1 hour, and the percentage of protective power was calculated. The results showed that the dose of 800 mg/kgBB gave the highest analgesic effect with a percent protection power of 65.28%, followed by doses of 400 mg/kgBB (52.4%) and 200 mg/kgBB (30.6%). The highest analgesic effect was achieved at a dose of 800 mg/kgBB, almost equivalent to the positive control. This shows the significant potential of purslane ethanol extract as an analgesic agent.

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References

Amalila, D., Samodra, G., & Silvia Febriana, A. (2021). Uji Analgetik Kombinasi Ekstrak Etanol Daun Blimbing Wuluh (Averrhoa bilimbi L.) dan Daun Kelor (Moringae Oliferae L.) pada Mencit Jantan Galur Swiss Webster. Jurnal Farmasi & Sains Indonesia, 4(2), 91–97.https://doi.org/10.52216/jfsi .vol 4 no 2 91-97

Andayani, D., Suprihartini, E., and Astuti, M. 2018. Efek Antiinflamasi Ekstrak Etanol Krokot (Portulaca oleracea, L.) pada Udema Tikus yang diInduksi Karagenin. JPSCR : Journal of Pharmaceutical Science and Clinical Research, 3(1): 43-49.

Lumintang. R. F., Wuisan, J., Wowor, P. M. 2015. "Uji Aktivitas Analgetik Ekstrak Etanol Kulit Batang Pohon Matoa (Pommetia Pinnata) Pada Menciu (Mus musculus)". Jurnal e-Biomedik.

Nurhalimah, H., N. Wijayanti, dan T.D. Widyaningsih. 2015. Efek antidiare ekstrak daun beluntas (Pluchea indica L)terhadap mencit jantan yang diinduksi bakteri Salmonella typhimurium. Jurnal Pangan dan Agroindustri.3(3): 1083–1094.

Sentat, T., & Pangestu, S.(2016). Uji Efek Analgesik Ekstrak Etanol Daun kersen (Muntingia calabura L.) pada Mencit Putih Jantan (Mus musculus) dengan Induksi Nyeri Asam Asetat. Jurnal Ilmiah Manuntung, 2(2), 147-153.

Syanjani, Muhammad. 2014. Uji Efektivitas Analgetik Ekstrak Etanol Daun Beluntas (Pluchea Indica L.) Pada Mencit Putih Jantan Dengan Metode Induksi Nyeri Cara Kimia. Skripsi. Akademi Farmasi Samarinda.

Tjay, T.H., dan Rahardja, K., 2015. Obat-Obat Penting: Khasiat, Penggunaan, dan Efek-Efek Sampingnya.

Wardoyo, A. V., & Oktarlina, R. Z. (2019). Tingkat Pengetahuan Masyarakat Terhadap Obat Analgesik Pada Swamedikasi Untuk Mengatasi Nyeri Akut Metode. Jurnal Ilmiah Kesehatan Sandi Husada, 10(2), 156–160. https://doi.org/10.35816/jiskh.v10i2.1 38

Yusuf, M., Wahidah, L. K., Widodo, S., Sari, P. G., % Kanedi, M. (2020). Analgesik activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetumgnemon L.) Leaves in mice. Biological and Pharmaceutical Sciences.

Zhou, Y., Xin, H., Rahman, K., Wang, S., Peng, C., and Zhang, H. 2015. Portulaca oleracea L .: A Review of Phytochemistry and Pharmacological Effects. BioMed Research International, 2015: 1-11