Potensi Interaksi Obat pada Pasien Geriatri Diabetes Melitus Tipe 2 di RSUD Dr. Moewardi Surakarta Tahun 2023

Dilla Ayu Septiyani; Adhi Wardhana Amrullah; Rolando Rahardjoputro

doi:10.61132/obat.v2i5.674

Authors

Dilla Ayu Septiyani Universitas Kusuma Husada Surakarta
Adhi Wardhana Amrullah Universitas Kusuma Husada Surakarta
Rolando Rahardjoputro Universitas Kusuma Husada Surakarta

DOI:

https://doi.org/10.61132/obat.v2i5.674

Keywords:

Diabetes melitus, Drug interactions, Geriatrics

Abstract

Type 2 diabetes mellitus represents a persistent metabolic dysfunction marked by elevated blood glucose levels attributable to insulin resistance. Geriatrics pertains specifically to individuals aged 60 years and older. Managing diabetes mellitus necessitates intricate therapeutic interventions, often comprising single or combined pharmacological agents aimed at achieving euglycemia. The concurrent administration of multiple medications, termed polypharmacy, amplifies the likelihood of pharmacological interactions. This investigation endeavors to delineate potential drug interactions observed in geriatric inpatients afflicted with type 2 diabetes mellitus at Dr. Moewardi Regional General Hospital in Surakarta throughout the calendar year 2023. The study adopted a descriptive observational design employing a cross-sectional approach. Data collection was conducted retrospectively through purposive sampling based on the medical records of geriatric patients at Dr. Moewardi Regional General Hospital in Surakarta. Inclusion criteria encompassed patients aged 60 years and older diagnosed with type 2 diabetes mellitus who had been hospitalized. Exclusion criteria included incomplete or illegible medical records, patients diagnosed with anemia and hemoglobinopathies, and those who expired during treatment. The findings revealed that out of 100 patients, 96 experienced drug interactions. Most patients (47.00%) were aged between 66 and 74 years. Females constituted a larger proportion (51.00%) of the patient cohort. Among hospitalized patients, 83 (83.00%) were admitted for 2-6 days. A total of 70 patients (70.00%) were prescribed between 4 and 13 medications. The predominant severity level of drug interactions was moderate, comprising 1,017 cases (74.60%). Pharmacodynamic mechanisms accounted for most drug interactions observed, totaling 1,054 cases (77.30%).

Downloads

Download data is not yet available.

References

Agustin, O. A., & Fitrianingsih, F. (2021). Kajian Interaksi Obat Berdasarkan Kategori Signifikansi Klinis Terhadap Pola Peresepan Pasien Rawat Jalan Di Apotek X Jambi. Electronic Journal Scientific of Environmental Health And Disease, 1(1), 1–10. https://doi.org/10.22437/esehad.v1i1.10759

Alfiani, D. N., Yani, A., & Hermanto, R. A. (2021). Mellitus Tipe Ii Rawat Inap Di Rsu Holistic Purwakarta. 5(1), 9–17.

Andriane, Y., Sastramihardja, H. S., & Ruslami, R. (2016). Determinan Peresepan Polifarmasi pada Resep Rawat Jalan di Rumah Sakit Rujukan. Global Medical & Health Communication (GMHC), 4(1), 66. https://doi.org/10.29313/gmhc.v4i1.2000

Anggriani, Y., Rianti, A., Pratiwi, A. N., & Puspitasari, W. (2020). Evaluasi Penggunaan Insulin pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Rumah Sakit X di Jakarta Periode 2016-2017. Jurnal Sains Farmasi & Klinis, 7(1), 52. https://doi.org/10.25077/jsfk.7.1.52-59.2020

Chia, C. W., Egan, J. M., & Ferrucci, L. (2018). Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk. Circulation Research, 123(7), 886–904. https://doi.org/10.1161/CIRCRESAHA.118.312806

Fikry, A., & Sidqi Aliya, L. (2019). Pola Terapi pada Pasien Diabetes Melitus Tipe 2 di Instalasi Rawat Inap RSUD dr H. Moch. Ansari Saleh, Banjarmasin Periode Januari-Maret 2018. Saintech Farma, 12(1), 54–59.

Gupta, R. C., Chang, D., Nammi, S., Bensoussan, A., Bilinski, K., & Roufogalis, B. D. (2017). Interactions between antidiabetic drugs and herbs: An overview of mechanisms of action and clinical implications. Diabetology and Metabolic Syndrome, 9(1), 1–12. https://doi.org/10.1186/s13098-017-0254-9

Herdaningsih, S., Muhtadi, A., Lestari, K., & Annisa, N. (2016). Potential of Drug-Drug Interaction in Polypharmacy Prescription: Retrospective Study on a Drugstore in Bandung. Indonesian Journal of Clinical Pharmacy, 5(4), 288-292.

IDF. (2021). Diabetes worldwide in 2021. In International Diabetes Federation.

Imelda, S. (2019). Faktor-Faktor Yang Mempengaruhi Terjadinya diabetes Melitus di Puskesmas Harapan Raya Tahun 2018. 8(1), 28–39.

Kemenkes. (2015). Tahun 2030 Prevalensi Diabetes Mellitus Di Indonesia Mencapai 21.3 Juta.

Kementerian Kesehatan Republik Indonesia. (2014). Peraturan menteri kesehatan republik Indonesia nomor 79 tahun 2014 tentang penyelenggaraan pelayanan kesehatan geriatri di rumah sakit.

Kementerian Kesehatan Republik Indonesia. (2020). Keputusan Menteri Kesehatan Republik Indonesia Nomor HK.01.07/MENKES/603/2020. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Diabetes Mellitus Tipe 2 Dewasa.

Kementrian Kesehatan RI. (2018). Riset Kesehatan Dasar. Jakarta: Kemenkes RI.

Kurniawati, F., Yasin, N. M., Dina, A., Atana, S., Hakim, S. N. (2020). Kajian Adverse Drug Reactions Terkait Interaksi Obat di Bangsal Rawat Inap Rumah Sakit Akademik UGM Study on Adverse Drug Reactions Related to Drug Interactions on Medical Ward Teaching Hospital UGM. 10(4), 297–308.

Lawere, R. A., Tiwow, G. A., Palandi, R. R., Saroinsong, Y. F., & Mongi, J. (2021). Evaluasi Interaksi Obat Diabetes Pada Pasien Geriatri Di Instalasi Rawat Inap Rumah Sakit Lapangan Sawang Kabupaten Sitaro Tahun 2016. Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical), 4(2), 8-14.

Mouly, S., Lloret-Linares, C., Sellier, P. O., Sene, D., & Bergmann, J. F. (2017). Is the clinical relevance of drug-food and drug-herb interactions limited to grapefruit juice and Saint-John’s Wort?. Pharmacological Research, 118, 82-92.

Musdalipah, M., Nurhikma, E., & Sartika, S. (2017). Identifikasi DRPs (Drug Related Problems) Penderita ISPA Pasien Pediatrik Di Instalasi Farmasi Rumah Sakit. Warta Farmasi, 6(1), 37–49. https://doi.org/10.46356/wfarmasi.v6i1.70

Nurlaelah, I., Mukaddas, A., & Faustine, I. (2015). Kajian Interaksi Obat Pada Pengobatan Diabetes Melitus (Dm) Dengan Hipertensi Di Instalasi Rawat Jalan Rsud Undata Periode Maret-Juni Tahun 2014. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 1(1), 35–41. https://doi.org/10.22487/j24428744.2015.v1.i1.4833

Nusair, M. B., Al-Azzam, S. I., Arabyat, R. M., Amawi, H. A., Alzoubi, K. H., & Rabah, A. A. (2020). The Prevalence And Severity Of Potential Drug-Drug Interactions Among Adult Polypharmacy Patients At Outpatient Clinics In Jordan. Saudi Pharmaceutical Journal, 28(2), 155-160.

Oktarlina, R. Z., & Gumantara, M. P. B. (2017). Perbandingan monoterapi dan kombinasi terapi sulfonilurea-metformin terhadap pasien diabetes melitus tipe 2. Medical Journal of Lampung University [MAJORITY], 6(1).

Rahayu, S., & Hendera, H. (2018). Interaksi Antar Obat Pada Peresepan Pasien Rawat Inap Rumah Sakit X Dengan Menggunakan Aplikasi Medscape. Journal of Current Pharmaceutical Sciences, 1(2), 75–80.

Rasdianah, N., Madania, M., & Pakaya, M. (2023). Studi Interaksi Obat Pasien Diabetes Melitus Tipe 2 dengan penyakit penyerta : Studi Kasus Rumah Sakit X Gorontalo. Journal Syifa Sciences and Clinical Research, 5(1), 192–199. https://doi.org/10.37311/jsscr.v5i1.8731

Sulistiana, R. (2020). Factors associated with mental health disorders among elderly with diabetes melitus in Indonesia. Jurusan Ilmu Kesehatan Masyarakat Universitas Negeri Semarang, 78.

Susilo, R., & Hidayati, N. R. (2018). Kajian Potensi Interaksi Obat Pada Resep Pasien Diabetes RSUD Gunung Jati Kota Cirebon Study Of Drug Interaction Potency On Diabetes Mellitus Patient’s Prescription In Outpatient Gunung Jati Hospital Cirebon City Interaksi obat dapat menghasilkan efek y. 1(2), 94-99.

Van Den Berg, J. P., Vereecke, H. E. M., Proost, J. H., Eleveld, D. J., Wietasch, J. K. G., Absalom, A. R., & Struys, M. M. R. F. (2017). Pharmacokinetic and pharmacodynamic interactions in anaesthesia. A review of current knowledge and how it can be used to optimize anaesthetic drug administration. British Journal of Anaesthesia, 118(1), 44–57. https://doi.org/10.1093/bja/aew312