Modification of Gemifloxacin Drug Antibacterial to Promising Anti-Prostate Cancer PC3 Azomethine Compounds: Synthesis and  in Vitro Studies

Rand Thair Abdulkader; Reyam H. Marah; Aqeel Mohamed; Abbas K. Abbas

doi:10.61132/obat.v2i5.665

Authors

Rand Thair Abdulkader Al- Karkh University of Science
Reyam H. Marah Al- Karkh University of Science
Aqeel Mohamed Department of Medical Lab Technique
Abbas K. Abbas Ministry of Agriculture

DOI:

https://doi.org/10.61132/obat.v2i5.665

Keywords:

Antibacterial, Antibiotic, Gemifloxacin, Cancer

Abstract

In this study, we report a novel azomethine derivatives synthesis (H and G) by reacting pure Gemifloxacin drugs with 2-aminobenzaldehyde and 2-methylbenzaldehyde. Spectroscopic techniques, such as FT‐IR spectroscopy, characterized the derivatives (G and H). All the synthesized derivatives (G and H) were evaluated in vitro against microorganisms such as Bacillus subtilis and E. coli by zone inhibition method and screened for antimicrobial activities and anti-Prostate cancer PC3 cell viability cell lines.

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