Kajian Beyond Use Date Sediaan Injeksi di Salah Satu Rumah Sakit Kota Bandung Tahun 2024
DOI:
https://doi.org/10.61132/obat.v3i1.1071Keywords:
beyond use date, injection preparations, hospitalAbstract
Beyond Use Date or BUD is the time limit for a non-sterile or sterile mixed preparation not to be stored and used, calculated from the date or time of compounding. BUD indicates the time limit for the preparation to be in a stable state so it is very necessary to determine the BUD time. This article aims to review BUD information on 20 types of injection preparations in one of the Bandung City Hospitals conducted in 2024 using information collection methods from various sources such as related drug brochures, LexiDrug, and Drug Information Handbook. The results of the study of 13 therapeutic classes with 20 types of injection preparations show that each sterile preparation has different characteristics (active substance, solvent, dosage form and its components, duration of therapy, and storage), thus affecting the stability after reconstitution of each preparation, both those determined by each pharmaceutical industry and information obtained from LexiDrug and Drug Information Handbook. The results of this study can be used as a reference in making more applicable guidelines in determining the BUD of injection preparations in one of the Bandung City Hospitals.
Downloads
References
Anggianingrum, R., Rezka, F. R., Samsul, H., dan Deni, S. 2023. Sosialisasi Batas Penggunaan Obat atau Beyond Use Date (BUD) di Apotek Kimia Farma 188. 1 (4)
Ainni, A. N., Anwar, S., Eka, W. H., Muh, H. K., Vinca, E., Agung, K., dan Satria, E. 2024. Perhitungan Beyond Use Date Obat Rumah Tangga di Masyarakat Mergosono, Kebumen untuk Masa Kadaluwarsa. Jurnal Mandala Pengabdian Masyarakat. 5 (1).
Cokro, F., Arrang, S. T., Solang, J. A. N., dan Sekarsari, P. 2021. The Beyond-Use Date Perception of Drugs in North Jakarta, Indonesia. Indonesian Journal of Clinical Pharmacy. 10 (3).
Dewi, N. L. P. A. 2024. Gambaran Pengetahuan Tenaga Kesehatan Tentang Beyond Use Date Sediaan Farmasi. Journal Scientific of Mandalika. 5 (1).
Dwijayanti, S., Sylvi, I., dan Eko, S. 2016. Profil Kompatibilitas Sediaan Obat Intravena dengan Pelarut pada Pasien Intensive Care Unit. Jurnal Farmasi Klinik Indonesia. 5 (2).
Engel, J. dan Nicole, L. 2016. Guidelines for the Establishment of Appropiate Beyond Use Dating of Sterile Compounded Admixtures. Hosp Pharm. 51 (8).
Fu’adah, I. T., Andriyani, R. F., Diah, P. S., Nur, H., Sheila M. U., Andika, A. P. A., Fitria, A. S., dan Teungku, R. S. 2023. Edukasi Pentingnya Memahami dan Mematuhi BUD (Beyond Use Date) pada Obat Di Kalangan Masyarakat Kecamatan Pamulang. Jurnal Abdi Masyarakat. 4 (2).
Genatrika, E., Ika, P., Susi, A. K. dan Teuku, N. S. S., 2022. Suitability In Compounding Sterile Preparations: An Observational Study In A Referral Hospital. Journal of Pharmacy & Pharmacognosy Research. 10 (2).
Khairi, N., Indrisari, M., Aisyah, A. N., Fajriansyah, F., dan Rumata, N. R. 2023. Edukasi Beyond Use Date (BUD) Pada Pasien Di Puskesmas Makassau Makassar. Jurnal Pengabdian Masyarakat Almarisah, 2(3).
Lacy, C.F., L.L. Armstrong, M.P. Goldman and L.L. Lance (editors). 2009. Drug Information Handbook. 17th Edition. American: American Pharmacists Association.
Menteri Kesehatan Republik Indonesia. 2016. Peraturan Menteri Kesehatan Republik Indonesia Nomor 72 Tahun 2016 Tentang Standar Pelayanan Kefarmasian di Rumah Sakit. Jakarta: Menteri Kesehatan RI.
Pratiwi, G., A. R., Ramadhani, Y. Arina, U. Alta, M. Tari, O. Indriani, G. Nugraha, Suprayetno. 2023. Penyuluhan Tentang Beyond Use Date (BUD) pada Obat-obatan. Jurnal Pengabdian, 2(1): 25-26.
Priyoherianto, A., Valiandri, P., dan Merry, P. C. 2023. Tingkat Pengetahuan Pasien Terhadap Beyond Use date (BUD) Obat Racikan di Apotek Kimia Farma 180 Pahlawan, Sidoarjo. Jurnal Farmasi Indonesia. 4 (1).
Rahmawati, R., Fita, R., dan Syed, A. S. S. 2018. Problem Kompatibilitas dan Stabilitas Pencampuran Sediaan Intravena pada Pasien Anak di RSUP Dr. Sardjito. Jurnal Farmasi. 7 (1).
Rambe, R., Evi, D. G., Zulmai, R., Erma, S., dan Athaillah. 2023. Evaluasi Dispensing Sediaan Steril Antibiotik pada Pasien Pediatri Di Rumah Sakit X. 3 (2).
Sagitha, G.E., Suharjo, Yulistiani, Isnaeni. 2023. Uji Stabilitas Sediaan Ampisillin Sulbaktam Setelah Rekonstitusi. Jurnal Sains dan Ilmu Farmasi. 8(1).
Spencer, S., Heather, I., Patricia, H., Courtney K., Ryan, R., Alan, E. G. dan Michael, G., 2018. Intravenous Push Administration of Antibiotics: Literature and Considerations. Hospital Pharmacy. 53 (3).
Trissle LA. 2013. Handbook on Injectable Drugs. 17th. Bethesda : American Society of Health-System Pharmacists.
USP. 2014. Chapter 795: Pharmaceutical Compounding - Nonsterile Preparations. Tersedia secara online di: https:// www.uspnf.com/sites/default/files/usp_ pdf/EN/USPNF/re visions/gc795.pdf. [Diakses pada tanggal 12 Juli 2024]
USP. 2019. USP Compounding Standards and Beyond-Use Dates (BUDs). Tersedia secara online di https://www.usp.org/sites/default/files/usp/document/our-work/compounding/usp-bud-factsheet.pdf [Diakses pada tanggal 11 Juli 2024].
USP. 2019. Chapter 797: Pharmaceutical Compounding - Sterile Preparations. Tersedia secara online di https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/revisions/gc-797-postponement-rb-notice-20191122.pdf [Diakses pada tanggal 11 Juli 2024].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
