Kadar CRP pada Pasien Tuberkulosis Paru dengan Terapi Obat Anti Tuberkulosis di Puskesmas Oebobo Kota Kupang

Ni Ketut Yuliana Sari; Agnes Rantesalu; Kuntum Ekawati Nurdin

doi:10.61132/vitamin.v2i1.185

Authors

Ni Ketut Yuliana Sari Poltekkes Kemenkes Kupang
Agnes Rantesalu Poltekkes Kemenkes Kupang
Kuntum Ekawati Nurdin Poltekkes Kemenkes Kupang

DOI:

https://doi.org/10.61132/vitamin.v2i1.185

Keywords:

C-Reactive Protein, OAT, Tuberkulosis

Abstract

Tuberculosis (TB) is one of the top 10 causes of death worldwide. Anti-tuberculosis drugs (OAT) are the most important component of TB treatment. CRP can be used as a marker of tuberculosis activity and severity and can predict the course of the disease. This study aimed to determine CRP levels in TB patients at the Oebobo Community Health Centre in Kupang City as a monitor of response to TB treatment. The research design was observational analytic using a cross sectional approach by measuring CRP levels in the form of high sensitivity CRP in pulmonary TB patients with OAT therapy. The results showed that of the 27 respondents (20 men, 7 women), 18 people (66.66%) had CRP ≤ 10 mg/L and 9 people (33.33%) had CRP > 10 mg/L. Based on the length of treatment, CRP levels > 10.0 mg/L were most prevalent in respondents who were undergoing intensive treatment, namely 6 people (22.22%). Respondents with advanced treatment had more CRP levels ≤ 10.0 mg/L (26.63%) than > 10.0 mg/L (11.11%).

Author Biography

Agnes Rantesalu, Poltekkes Kemenkes Kupang

References

Agyeman, A. A., Asenso. R. O. (2017). Tuberculosis—an overview, Journal of Public Health and Emergency, 2017;1:7.

Arnadi, N. G., Suryadhana, Kasjmir. Y. I. (2015). Ilmu Penyakit Dalam, Edisi VI. Jakarta: Interna Publishing.

Azizi, F. H., Husin, U. A., Rusmartini, T. (2014). Gambaran Karakteristik Tuberkulosis Paru dan Ekstra Paru di BBKPM Bandung Tahun 2014. Prosiding penelitian sivitas akademika unisba (kesehatan). Bandung: UNISBA.

Dinas Kesehatan Kota Kupang. (2018). Profil Kesehatan Kota Kupang 2018. Dinas Kesehatan Kota Kupang.

Ergiana, S. (2022). Hubungan Kadar C-Reactive Protein Dengan Jumlah Leukosit Penderita Tuberkulosis Paru Pada Fase Pengobatan 0 Dan 2 Bulan Di BKPM Purwoketo. Jurnal Surya Medika, 8 (2): 62-77.

Fahlafi, A. J.. 2014. Simulasi Model Sel Limfosit T CD8+ pada infeksi Mycobacterium tuberculosis. Skripsi. Fakultas Sains dan Teknik, Universitas Islam Maulana Malik Ibrahim, Malang.

Irianti, R. N. T., Kuswandi., Yasin, N. M., Kusaningtyas. R. A. (2016). Mengenal Anti Tuberkulosis. Yogyakarta: Universitas Gajah Mada.

Kementerian Kesehatan RI. (2016). Penanggulangan Tuberkulosis. Jakarta: Permenkes TB No.67 thn 2016.pdf.

Kementerian Kesehatan RI. (2017). Modul Pelatihan Pencegahan Pengedalian Penyakit TB. Jakarta: Direktorat Jenderal Pencegahan dan Pengendalian Penyakit Menular.

Kementerian Kesehatan RI. (2019). Profil Kesehatan Indonesia 2018. Jakarta: Kementerian Kesehatan RI.

Khairunnisa, A. (2021). Gambaran Kadar C-Reactive Protein (CRP) Pada Pasien Tuberkulosis Paru MDR (Multidrug Resistance). Karya Tulis Ilmiah. Teknologi Laboratorium Medis Poltekkes Kemenkes, Semarang.

Kusmiati, T., Mertaniasih N. M., Eko Putranto J. N., Suprapti, B., Soedarsono, Luthfah, N., Koesoemoprodjo, W., Sari, A. P. (2021). The role of C-Reactive protein as an inflammatory marker to predict prolonged QTc interval in rifampicin-resistant tuberculosis patients: A case-control study. Ann Med Surg (Lond), 2021 Oct 3;70:102899.

Kwas, H., Guermazi, E., Zendah, I., Jemia, E.B., Khattab, A., Hkouaja, I., Ghedira, H. (2015). C-reactive protein and pulmonary tuberculosis: What correlation with disease severity. European Respiratory Journal, 46 (suppl 59) PA2751.

Naomi, A. D., Dilangga. P., Ramadhian.M., Marlina N. (2016). Penatalaksanaan Tuberkulosis Paru Kambuh pada Wanita Usia 32 Tahun Di Wilayah Rajabasa. Skripsi. Universitas Lampung, Lampung.

Nasty, D. (2018). Gambaran C-Reactive Protein Pada Penderita Tb Paru Yang Telah Didiagnosa Dokter Di RSUD Dr. Pringa di Medan. Karya Tulis Ilmiah. Jurusan Analis Kesehatan Politeknik Kesehatan Kemenkes, Medan.

Nehring, S.M., Goyal, A., Patel, B.,C. C Reactive Protein. (2021). In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK441843/.

Permana, A. (2020). Gambaran Kadar Hemoglobin (Hb) dan Leukosit Pada Penderita Tb Paru Dengan Lamanya Terapi Oat (Obat Anti Tuberculosis) Di Rumah Sakit Islam Jakarta Cempaka Putih. Open Journal System (OJS), 6 (2): 136-143.

Pramono, J.S. (2021). Tinjauan Literatur: Faktor Risiko Peningkatan Angka Insidensi Tuberkulosis. Jurnal Ilmiah Pannmed, 16 (1): 106-113.

Seno, A.O.M., Wardani, D.P.K., Supriyadi., Mulyanto, A. (2022). Perbandingan Kadar C-Reactive Protein Terhadap Fase Pemberian Obat Anti Tuberkulosis. The Journal Of Muhammadiyah Medical Laboratory technologist, 5 (2): 115-123.

Silalahi, T. N. (2013). Penilaian Kadar High Sensitivity C-Reactive Protein pada Subjek Sindrom Metabolik dan Obesitas. Tesis. Fakultas Kedokteran Universitas Sumatera Utara. Medan.

Simbolon, D., Mutiara, E., Lubis, R. (2019). Analisis Spasial dan Faktor Risiko Tuberkulosis Paru di Kecamatan Sidikalang, Kabupaten Dairi – Sumatera Utara Tahun 2018. BKM Journal of Community Medicine and Public Health, 35 (2): 65-71.

Soedarsono & Subiantoro, M. C. (2018). Changes of CRP Serum Levels in Pulmonary TB Patients with AFB Smear-Positive Sputum Before and Two Months After Receiving Anti-Tuberculosis Drug Treatment. Indian Journal of Tuberculosis.

Sunarmi & Kurniawaty. (2022). Hubungan Karakteristik Pasien TB Paru dengan Kejadian Tuberkulosis. Jurnal ‘Aisyiyah Medika, 7 (2): 182-187.

Tahumuri, A., Wongkar, M. C. P., & Rotty, L.W. A. (2017). Gambaran Laju Endap Darah Dan C-Reactive Protein Pada Pasien Tuberkulosis Paru Di Manado 2016. Jurnal Kedokteran Klinik (Jkk). 1(3): 16-18.

World Health Organization (WHO). (2020) The Global Tuberculosis Report. WHO.

Yuliani, N.N., Maria, I., Andre, L.T., Saal, N. (2019). Peran Pengawas Minum Obat Terhadap Keberhasilan Pengobatan Tuberkulosis dengan Strategi DOTS di Puskesmas Oebobo Kota Kupang. Jurnal Inovasi Kebijakan, 4(2), 31-41.