Frozen vs. Fresh Embryo Transfer dalam Program IVF: Sebuah Review Literatur tentang Implikasi terhadap Live  Birth Rate dan Risiko Preeklampsia

Maharani Chikita; Azniah Syam

doi:10.61132/protein.v3i3.1576

Authors

Maharani Chikita Universitas Mega Buana Palopo
Azniah Syam Universitas Mega Buana Palopo https://orcid.org/0000-0002-8451-3895

DOI:

https://doi.org/10.61132/protein.v3i3.1576

Keywords:

IVF, Frozen Embryo Transfer, Fresh Embryo Transfer, Live Birth Rate, Preeclampsia

Abstract

Infertility is a global health problem that has significant social and psychological impacts. Factors such as environmental and occupational factors, physical activity, and poor nutrition can increase the risk of infertility. Assisted reproductive technology (ART) is one of the main interventions used to treat infertility, with in vitro fertilization (IVF) being the most common method. In IVF, there are two methods of embryo transfer: frozen embryo transfer (FET) and fresh embryo transfer (ET). This study aims to compare the live birth rate between frozen and fresh embryo transfer in IVF programs and assess the risk of preeclampsia associated with both embryo transfer methods. A literature review was conducted by searching 20 scientific articles from PubMed, Google Scholar, and ScienceDirect using inclusion criteria and the PICO strategy and PRISMA flow chart. Inclusion criteria included publications from the last 10 years, English language, and human studies. The results showed that both methods produced comparable live birth rates (LBR) with FET slightly superior to ET, depending on the patient's condition and characteristics. On the other hand, there was a significantly increased risk of preeclampsia in FET, especially in patients using the artificial cycle protocol (AC-FET). The conclusion of this review is that FET and ET methods are effective in achieving pregnancy and there is an increased risk of preeclampsia in FET especially AC-FET which needs further consideration.

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References

Abdulrahim, B., Scotland, G., Bhattacharya, S., & Maheshwari, A. (2021). Assessing couples’ preferences for fresh or frozen embryo transfer: A discrete choice experiment. Human Reproduction, 36(11), 2891–2903. https://doi.org/10.1093/humrep/deab207

Aflatoonian, A., Maybodi, M. A. K., & ... (2016). Perinatal outcome in fresh versus frozen embryo transfer in ART cycles. International Journal of Reproductive BioMedicine, 14(3). https://pmc.ncbi.nlm.nih.gov/articles/PMC4899761/

Bagheri, R. B., Bazrafkan, M., Sabour, A., Ataei, M., Badehnoosh, B., Mashak, B., Khakifirooz, B., & Moghaddam, R. (2023). The comparison of pregnancy outcomes in fresh and frozen embryo transfer: A cross-sectional study. International Journal of Reproductive BioMedicine, 21(7), 551–556. https://doi.org/10.18502/ijrm.v21i7.13891

Bellver, J., Del Arco, A., Pellicer, A., Caracena, L., Serra, V., Labarta, E., Castillón, G., Fernández, G., Barrio, A., Ortega, I., Fernández, I., Torres, M., Ballesteros, A., Muñoz, E., Marqueta, J., Ferrando, M., Grañeras, Á., Bartha, J. L., Garrido, N., & García-Velasco, J. A. (2025). Risk of preeclampsia and other pregnancy complications in frozen single euploid embryo transfers after natural versus artificial endometrial preparation: A truncated randomized controlled trial. Placenta, 163, 1–7. https://doi.org/10.1016/j.placenta.2025.02.016

Blazquez, A., García, D., Vassena, R., Figueras, F., & Rodriguez, A. (2018). Risk of pre-eclampsia after fresh or frozen embryo transfer in patients undergoing oocyte donation. European Journal of Obstetrics & Gynecology and Reproductive Biology, 227, 27–31. https://doi.org/10.1016/j.ejogrb.2018.05.030

Ciraci, T., Kapudere, B., Cevrioglu, A. S., & Budak, O. (2025). The effect of fresh and frozen embryo transfer on maternal and perinatal results in pregnancy by assisted reproductive therapy. Reproductive Medicine: Endocrinology and Infertility, 31(1), 40–48. https://doi.org/10.21613/GORM.2025.1473

Epelboin, S., Labrosse, J., De Mouzon, J., Devaux, A., Gervoise-Boyer, M. J., Hesters, L., Jonveaux, P., Levy, R., Sermondade, N., Fauque, P., & Pessione, F. (2023). Higher risk of pre-eclampsia and other vascular disorders with artificial cycle for frozen-thawed embryo transfer compared to ovulatory cycle or to fresh embryo transfer following in vitro fertilization. Frontiers in Endocrinology, 14, Article 1182148. https://doi.org/10.3389/fendo.2023.1182148

Fan, L., Tang, N., Yao, C., Wei, X., Tang, Y., Li, J., & Huang, W. (2022). Association between fresh embryo transfers and frozen–thawed embryo transfers regarding live birth rates among women undergoing long gonadotropin-releasing hormone antagonist protocols. Frontiers in Cell and Developmental Biology, 10, Article 884677. https://doi.org/10.3389/fcell.2022.884677

Gullo, G., Basile, G., Cucinella, G., Greco, M. E., Perino, A., Chiantera, V., & Marinelli, S. (2023). Fresh vs. frozen embryo transfer in assisted reproductive techniques: A single center retrospective cohort study and ethical-legal implications. European Review for Medical and Pharmacological Sciences, 27(14), 6809–6823. https://doi.org/10.26355/eurrev_202307_33152

He, Y. (2022). Reduced live birth rate after frozen compared to fresh single poor cleavage-stage embryo transfer cycles: A retrospective study. Research Square, 1–13. https://doi.org/10.21203/rs.3.rs-1465521/v1

Pohjonen, E. M., Ahinko, K., Huhtala, H., Erkinaro, T., Lehto, J., Pellas, E., Vilmi-Kerälä, T., & Laivuori, H. (2024). Clinical features of preeclampsia and hypertensive disorders in pregnancies after different frozen embryo transfer regimens. Pregnancy Hypertension, 36, Article 101123. https://doi.org/10.1016/j.preghy.2024.101123

Roque, M., Haahr, T., Geber, S., Esteves, S. C., & Humaidan, P. (2019). Fresh versus elective frozen embryo transfer in IVF/ICSI cycles: A systematic review and meta-analysis of reproductive outcomes. Human Reproduction Update, 25(1), 2–14. https://doi.org/10.1093/humupd/dmy033

Shah, N., & Jayakrishnan, K. (2019). Obstetric and perinatal outcomes in pregnancies occurring as a result of fresh and thawed frozen embryo transfer. International Journal of Reproduction.

Smith, A. D. A. C., Tilling, K., Lawlor, D. A., & Nelson, S. M. (2019). Live birth rates and perinatal outcomes when all embryos are frozen compared with conventional fresh and frozen embryo transfer: A cohort study of 337,148 in vitro fertilisation cycles. BMC Medicine, 17(1), 1–13. https://doi.org/10.1186/s12916-019-1429-z

Wang, F., Wang, Q., Song, Y., Ding, J., Li, H., & Meng, Q. (2023). Programmed frozen embryo transfer cycles are associated with a higher risk of abnormal placental development: A retrospective cohort study of singleton live births. Frontiers in Endocrinology, 14, Article 1202044. https://doi.org/10.3389/fendo.2023.1202044

Wei, D., Sun, Y., Zhao, H., Yan, J., Zhou, H., Gong, F., Zhang, A., Wang, Z., Jin, L., Bao, H., Zhao, S., Xiao, Z., Qin, Y., Geng, L., Cui, L., Sheng, Y., Sun, M., Liu, P., Ding, L., … Chen, Z.-J. (2025). Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: Pragmatic, multicentre, randomised controlled trial. BMJ, 388, Article e081474. https://doi.org/10.1136/bmj-2024-081474

Wu, X., Zhou, W. J., Xu, B. F., Chen, Q., Xia, L., Zhao, S., Xu, H. H., Zhang, A. J., & Niu, Z. H. (2023). Association between transferred embryos and multiple pregnancy/live birth rate in frozen embryo transfer cycles: A retrospective study. Frontiers in Endocrinology, 13, Article 1073164. https://doi.org/10.3389/fendo.2022.1073164

Zaat, T., Zagers, M., Mol, F., Goddijn, M., van Wely, M., & Mastenbroek, S. (2021). Fresh versus frozen embryo transfers in assisted reproduction. Cochrane Database of Systematic Reviews, 2021(2), Article CD011184. https://doi.org/10.1002/14651858.CD011184.pub3

Zargar, M., Dehdashti, S., Najafian, M., & Choghakabodi, P. M. (2021). Pregnancy outcomes following in vitro fertilization using fresh or frozen embryo transfer. Jornal Brasileiro de Reprodução Assistida, 25(4), 570–574. https://doi.org/10.5935/1518-0557.20210024

Zhang, W., Xiao, X., Zhang, J., Wang, W., Wu, J., Peng, L., & Wang, X. (2018). Clinical outcomes of frozen embryo versus fresh embryo transfer following in vitro fertilization: A meta-analysis of randomized controlled trials. Archives of Gynecology and Obstetrics, 298(2), 259–272. https://doi.org/10.1007/s00404-018-4786-5