Synthesis and Characterization of Novel Bis-Schiff  Bases Based O-Tolidine

Mustafa A-Jabbar Al-Jumaili

doi:10.61132/obat.v2i6.828

Authors

Mustafa A-Jabbar Al-Jumaili University of Fallujah

DOI:

https://doi.org/10.61132/obat.v2i6.828

Keywords:

Schiff Base, O-Tolidine, Ligands

Abstract

Three novel Schiff base (A-C) was reported in this study by reaction of o-tolidine with three different aldehydes 2-bromobenzaldehyde, 3-hydroxybenzaldehyde, and 2,4-dihydroxybenzaldehyde to attain three novel Bis-Schiff Bases ligands in high yield (86-97%). Thin-layer chromatography (TLC) technique is used to monitor the reaction. These agents were characterized by 13C, 1H NMR, HRMS, FTIR, and melting point. The synthesized tcompounds (A-C) are expected to have considerable biological activity owing to their molecular structure, which incorporates essential imine functional groups.

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References

Vanitha, S., et al.,( 2023) Synthesis, spectral characterization, and biological studies of Schiff bases and their mixed ligand Zn (II) complexes with heterocyclic bases. Inorganic Nano-Metal Chemistry,. 53(8): p. 803-814.

Tsacheva, I., et al., (2023) Pharmacological activities of Schiff bases and their derivatives with low and high molecular phosphonates. Pharmaceuticals, 16(7): p. 938.

Mustafa, A. and M.A. Abid, (2023) Methodologies for the synthesis of 3, 4-ethylenedithiothiophene (EDTT) and its derivatives for use as semiconductor materials. Tetrahedron Letters. 124: p. 154588.

Raju, S.K., et al., (2022) Biological applications of Schiff bases: An overview. GSC Biological Pharmaceutical Sciences. 21(3): p. 203-215.

Aulakh, J.S., V. Kumar, and K.-H. Kim, (2019) A review of the applications of Schiff bases as optical chemical sensors. Trends in Analytical Chemistry. 116: p. 74e91.

Mustafa, A. and M.A. Abid, (2022) A review: Methodologies for the synthesis of anthra [2, 3-b] thiophene and naphtho [2, 3-b: 6, 7-b′] dithiophene fragments for organic semiconductor materials. Tetrahedron Letters. 113: p. 154258.

Ceramella, J., et al., (2022) A review on the antimicrobial activity of Schiff bases: Data collection and recent studies. Antibiotics,. 11(2): p. 191.

Tabassum, S., et al., (2013) New modulated design and synthesis of quercetin–Cu II/Zn II–Sn 2 IV scaffold as anticancer agents: in vitro DNA binding profile, DNA cleavage pathway and Topo-I activity. Dalton Transactions. 42(27): p. 10029-10041.

Gupta, K.C. and A.K. Sutar, (2008) Catalytic activities of Schiff base transition metal complexes. Coordination Chemistry Reviews. 252(12-14): p. 1420-1450.

Vieira, F.T., et al., (2010) Synthesis, characterization and biocidal activity of new organotin complexes of 2-(3-oxocyclohex-1-enyl) benzoic acid. European journal of medicinal chemistry. 45(3): p. 883-889.

Arroudj, S., et al., (2016) Synthesis, spectral, optical properties and theoretical calculations on schiff bases ligands containing o-tolidine. Optical Materials. 56: p. 116-120.