The role of Tenascin-X, Paraoxonase 1 and some other biochemical parameters in infertility women
DOI:
https://doi.org/10.61132/obat.v2i5.733Keywords:
hypothyroidism, infertility, Tenascin-X, Paraoxonase 1Abstract
The thyroid interact with the hypothalamic-pituitary reproductive axis. Tenascins (TN) are a group of versatile glycoproteins found in the extracellular matrix (ECM) that have distinct expression patterns in different tissues and stages of development, as well as in homeostasis tissue balance and during infections and diseases. Furthermore there are four types of family members that are referred as tenascin (-C,-R,-X, -W).Tenascin-X and tenascin-C have significant involvement in human diseases. The paraoxonase family consists of three genes: paraoxonase 1, paraoxonase 2, and paraoxonase 3. These genes have around 70% genetic sequence similarity and 60% same sequence of amino acid. Materials and Methods: 120 Sample of the current study were collected from married women aged 20 and 45 years after taking their information (age, height, weight, and health status in detail) to obtain suitable samples. Results : The anti-mullerian hormone showed significant decrease at (P<0.01) in hypothyroidism and increase significant in infertility at (P<0.01). Prolactin showed highly increase significant in hypothyroidism at (P<0.01) and in infertility women patients compared with women control . Luteinizing hormone level showed increase significant in hypothyroidism and infertility at (P<0.01) and follicle-Stimulating hormone level showed decrease significantly .The tenascin-X showed a high significant increase at (P<0.01) in hypothyroidism patient compared with control group. The optimal cut-off value tenascin-X was (10.382 pg/ml as cut-off value). The tenascin-X showed a high significant increase at in infertility with hypothyroidism women patient compared with control group. The optimal cut-off value for tenascin-X was (8.904 pg/ml) . Albumin level showed decrease significant in hypothyroidism at (P<0.01) and increase significant in hypothyroidism and infertility patients at (P<0.01) with control group. Conclusions: Hypothyroidism is associated with changes in the level of sex hormones, which is one of the main causes of infertility . tenascin-X were related with hypothyroidism. Hypothyroidism is associated with oxidative stress, PON-1conseder anti-oxidant and activity is changes in oxidative stress of different etiology.
Downloads
References
Acharya N, Acharya S, Shukla S, Inamdar SA, Khatri M, Mahajan SN. Gonadotropin levels in hypothyroid women of reproductive age group. J Obstet Gynaecol India. 2011 Oct;61(5):550–3.
Al-Naimi MS, Hussien NR, Rasheed HA, Al-Kuraishy HM, Al-Gareeb AI. Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study. J Adv Pharm Technol Res. 2018;9(3):113–8.
Azizi F, Raiszadeh F, Solati M, Etemadi A, Rahmani M, Arabi M. Serum paraoxonase 1 activity is decreased in thyroid dysfunction. J Endocrinol Invest. 2003 Aug;26(8):703–9.
Berardi AC, Oliva F, Berardocco M, la Rovere M, Accorsi P, Maffulli N. Thyroid hormones increase collagen I and cartilage oligomeric matrix protein (COMP) expression in vitro human tenocytes. Muscles Ligaments Tendons J. 2014 Jul;4(3):285–91.
Brown EDL, Obeng-Gyasi B, Hall JE, Shekhar S. The thyroid hormone axis and female reproduction. Int J Mol Sci. 2023;24(12):9815.
de Rycker C, Vandalem JL, Hennen G. Effects of 3,5,3’-triiodothyronine on collagen synthesis by cultured human skin fibroblasts. FEBS Lett. 1984 Aug;174(1):34–7.
Degen M, Scherberich A, Tucker RP. Tenascin-W: Discovery, Evolution, and Future Prospects. Front Immunol [Internet]. 2021 Feb 2;11. Available from: https://www.frontiersin.org/articles/10.3389/fimmu.2020.623305/full
Durrington P, Soran H. Paraoxonase 1: evolution of the enzyme and of its role in protecting against atherosclerosis. Curr Opin Lipidol. 2024;35(4):171–8.
Farwell AP, Dubord-Tomasetti SA. Thyroid hormone regulates the extracellular organization of laminin on astrocytes. Endocrinology. 1999 Nov;140(11):5014–21.
Garrity JA, Bahn RS. Pathogenesis of graves ophthalmopathy: implications for prediction, prevention, and treatment. Am J Ophthalmol. 2006 Jul;142(1):147–53.
Gounden V, Vashisht R, Jialal I. Hypoalbuminemia. In Treasure Island (FL); 2024.
Green C, Ghali N, Akilapa R, Angwin C, Baker D, Bartlett M, et al. Classical-like Ehlers–Danlos syndrome: a clinical description of 20 newly identified individuals with evidence of tissue fragility. Genet Med. 2020;22(10):1576–82.
Hasan SM, Mohammed AK, Taha AM. Measurement of paraoxonase-1, visfatin levels in Iraqi diabetic and diabetic with hypothyroidism. Biomedicine. 2022;42(1):165–8.
Hasegawa Y, Kitahara Y, Osuka S, Tsukui Y, Kobayashi M, Iwase A. Effect of hypothyroidism and thyroid autoimmunity on the ovarian reserve: A systematic review and meta‐analysis. Reprod Med Biol. 2022;21(1):e12427.
He Z, Ouyang Q, Chen Q, Song Y, Hu J, Hu S, et al. Molecular mechanisms of hypothalamic-pituitary-ovarian/thyroid axis regulating age at first egg in geese. Poult Sci. 2024;103(3):103478.
Iancu ME, Albu AI, Albu DN. Prolactin Relationship with Fertility and In Vitro Fertilization Outcomes-A Review of the Literature. Pharmaceuticals (Basel). 2023 Jan;16(1).
Kunachowicz D, Ściskalska M, Kepinska M. Modulatory effect of lifestyle-related, environmental and genetic factors on paraoxonase-1 activity: a review. Int J Environ Res Public Health. 2023;20(4):2813.
Lee M, Ben-Rafael Z, Meloni F, Mastroianni L, Flickinger GL. Relationship of human oocyte maturity, fertilization, and cleavage to follicular fluid prolactin and steroids. J Vitr Fertil embryo Transf. 1987;4:168–72.
Liang G, Wang S, Shao J, Jin YJ, Xu L, Yan Y, et al. Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis. Circ Res. 2022 May;130(11):1647–59.
Lima FR, Trentin AG, Rosenthal D, Chagas C, Moura Neto V. Thyroid hormone induces protein secretion and morphological changes in astroglial cells with an increase in expression of glial fibrillary acidic protein. J Endocrinol. 1997 Jul;154(1):167–75.
Magnan B, Bondi M, Pierantoni S, Samaila E. The pathogenesis of Achilles tendinopathy: a systematic review. Foot ankle Surg Off J Eur Soc Foot Ankle Surg. 2014 Sep;20(3):154–9.
Miller WL. Tenascin-X-Discovery and Early Research. Front Immunol. 2020;11:612497.
MuraleedharaN N, BeeguM MS. Association between Serum Albumin and Hypothyroidism in Preeclampsia: A Case-control Study. J Clin Diagnostic Res. 2021;15(6).
Rahman MM, Amin MR. relationship between hypoalbuminaemia and thyroid hormone status in patient with NEPHROTIC SYNDROME. Endocr Pract. 2019;25:323.
Reinhardt W, Mülling N, Behrendt S, Benson S, Dolff S, Führer D, et al. Association between albuminuria and thyroid function in patients with chronic kidney disease. Endocrine. 2021;73:367–73.
Shi D, Du J, Kang H, Feng L, Liu F. The effect of subclinical hypothyroidism on hormonal and metabolic profiles and ovarian morphology in patients with polycystic ovary syndrome: a cross-sectional study. Gynecol Endocrinol. 2024;40(1):2358219.
Sivanandy MS, Ha SK. The Role of Serum Anti-Mullerian Hormone Measurement in the Diagnosis of Polycystic Ovary Syndrome. Diagnostics (Basel, Switzerland). 2023 Feb;13(5).
Speek M, Barry F, Miller WL. Alternate promoters and alternate splicing of human tenascin-X, a gene with 5′ and 3′ ends buried in other genes. Hum Mol Genet. 1996;5(11):1749–58.
Supuran CT. Paraoxonases. In: Metalloenzymes. Elsevier; 2024. p. 93–9.
Torun AN, Kulaksizoglu S, Kulaksizoglu M, Pamuk BO, Isbilen E, Tutuncu NB. Serum total antioxidant status and lipid peroxidation marker malondialdehyde levels in overt and subclinical hypothyroidism. Clin Endocrinol (Oxf). 2009 Mar;70(3):469–74.
Yao J, Eghbali M. Decreased collagen gene expression and absence of fibrosis in thyroid hormone-induced myocardial hypertrophy. Response of cardiac fibroblasts to thyroid hormone in vitro. Circ Res. 1992 Oct;71(4):831–9.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.