Potensi Interaksi Obat di Sistem Pencernaan pada Resep Apotek Kota Bandung, November 2023

Authors

  • Shafira Galuh Peratiwi Universitas Padjadjaran
  • Raden Maya Febriyanti Universitas Padjadjaran

DOI:

https://doi.org/10.61132/obat.v2i4.570

Keywords:

drug interactions, gastrointestinal drugs, pharmacist

Abstract

Medications used for gastrointestinal (GI) disease therapy are widely prescribed or over-the-counter, ranking among the top 10 prescribed and sold globally. These drugs are often concurrently used with other medications, leading to potential drug interactions that can impact their effectiveness. However, the identification of potential interaction severity remains limited. This study focuses on identifying drug interactions in patients with digestive disorders through common prescriptions in Bandung city in November 2023. Out of 50 analyzed prescriptions, 20 potential drug interactions were identified, comprising 8 minor and 12 moderate interactions, with no major interactions. The findings underscore the pharmacist's crucial role in counseling and providing drug information to enhance therapy effectiveness and patients' quality of life.

Downloads

Download data is not yet available.

References

DrugBank. (2023). Drug Interaction Checker. Diakses dari https://go.drugbank.com/drug-interaction-checker

Drugs.com. (2023). Drug Interaction Checker. Diakses dari https://www.drugs.com/drug_interactions.html

Garin, N., Sole, N., Lucas, B., Matas, L., Moras, D., Rodrigo-Troyano, A., Gras-Martin, L., & Fonts, N. (2021). Drug related problems in clinical practice: A cross-sectional study on their prevalence, risk factors and associated pharmaceutical interventions. Scientific Reports, 11(1), 883. https://doi.org/10.1038/s41598-020-80560-2

Iyer, S., Wagh, B. R., Godbole, D. D., Deshmukh, S. S., & Deshpande, P. R. (2019). Identification and assessment of potential drug–drug interactions in intensive care unit patients. Indian Journal of Critical Care Medicine, 23(4), 170–174. https://doi.org/10.5005/jp-journals-10071-23147

Jabłońska, B., & Mrowiec, S. (2023). Gastrointestinal Disease: New diagnostic and therapeutic approaches. Biomedicines, 11(5), 1420. https://doi.org/10.3390/biomedicines11051420

Jones, S. L., & Blikslager, A. T. (2004). Disorders of the gastrointestinal system. In A. T. Blikslager (Ed.), Equine Internal Medicine (pp. 769–949). Elsevier. https://doi.org/10.1016/B0-72-169777-1/50015-9

Kemenkes. (2024). Apa itu obat? Diakses dari https://farmalkes.kemkes.go.id/ufaqs/apa-itu-obat/

Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., Hoad, C. L., Jedamzik, P., Madla, C. M., Maliepaard, M., Marciani, L., Maruca, A., Parrott, N., Pávek, P., Porter, C. J. H., Reppas, C., van Riet-Nales, D., Rubbens, J., Statelova, M., … Corsetti, M. (2019). The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences, 134, 31–59. https://doi.org/10.1016/j.ejps.2019.04.003

Lisni, I., Gumilang, N. E., & Kusumahati, E. (2021). Potensi medication error pada resep di salah satu apotek di Kota Kadipaten. Jurnal Sains Dan Kesehatan, 3(4), 558–568. https://doi.org/10.25026/jsk.v3i4.564

Litou, C., Effinger, A., Kostewicz, E. S., Box, K. J., Fotaki, N., & Dressman, J. B. (2019). Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: A PEARRL review. Journal of Pharmacy and Pharmacology, 71(4), 643–673. https://doi.org/10.1111/jphp.12983

Medscape. (2023). Drug Interaction Checker. Diakses dari https://reference.medscape.com/drug-interactionchecker

Ni, X.-F., Yang, C.-S., Bai, Y.-M., Hu, Z.-X., & Zhang, L.-L. (2021). Drug-related problems of patients in primary health care institutions: A systematic review. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.698907

Niu, J., Straubinger, R. M., & Mager, D. E. (2019). Pharmacodynamic drug–drug interactions. Clinical Pharmacology & Therapeutics, 105(6), 1395–1406. https://doi.org/10.1002/cpt.1434

Rahayu, S. (2018). Interaksi antar obat pada perepresan pasien rawat inap pediatrik Rumah Sakit X dengan menggunakan aplikasi Medscape (Drug interaction between the prescribing pediatric inpatients at Hospital X using Medscape applications). Medscape. Diakses dari www.medscape.com

Rusli. (2018). Farmasi Klinis. Jakarta: Kementerian Kesehatan RI.

Sadowski, D. C. (1994). Drug interactions with antacids. Drug Safety, 11(6), 395–407. https://doi.org/10.2165/00002018-199411060-00002

Shara Shorea Pratiwi. (2018). 739-1736-1-SM. Case based reasoning diagnosis gangguan pencernaan pada anak menggunakan metode similarity cosine coefficient.

Tharanon, V., Putthipokin, K., & Sakthong, P. (2022). Drug-related problems identified during pharmaceutical care interventions in an intensive care unit at a tertiary university hospital. SAGE Open Medicine, 10, 205031212210908. https://doi.org/10.1177/20503121221090881

Published

2024-07-19

How to Cite

Shafira Galuh Peratiwi, & Raden Maya Febriyanti. (2024). Potensi Interaksi Obat di Sistem Pencernaan pada Resep Apotek Kota Bandung, November 2023. OBAT: Jurnal Riset Ilmu Farmasi Dan Kesehatan, 2(4), 224–235. https://doi.org/10.61132/obat.v2i4.570

Similar Articles

<< < 1 2 3 4 

You may also start an advanced similarity search for this article.