Potensi Tanaman Obat Tradisional Indonesia sebagai Agen Bio Aktif Penunjang Kesehatan Tulang

Cut Massyitah Thaib; Artha Sianipar; Siti Nurbaya; Katarina Riris Teresia; Ade Irma Suryani; Eva Diansari Marbun

doi:10.61132/obat.v3i5.1593

Authors

Cut Massyitah Thaib Universitas Sari Mutiara Indonesia
Artha Sianipar Universitas Sari Mutiara Indonesia
Siti Nurbaya Universitas Sari Mutiara Indonesia
Katarina Riris Teresia Universitas Sari Mutiara Indonesia
Ade Irma Suryani Universitas Sari Mutiara Indonesia
Eva Diansari Marbun Universitas Sari Mutiara Indonesia

DOI:

https://doi.org/10.61132/obat.v3i5.1593

Keywords:

Osteoporosis, Traditional-Medicinal-Plants, Alkaline-Phosphate

Abstract

Abstrak. Osteoporosis is a degenerative bone disease characterized by a decrease in bone mass and strength, particularly in postmenopausal women. Traditional plant-based therapy presents an attractive alternative given the rich local bioactive potential and limited access to pharmacological treatments. One important biochemical indicator in bone regeneration is the level of alkaline phosphatase (ALP). The aim of this study is to evaluate the potential of various Indonesian traditional medicinal plants as bioactive agents in the prevention of osteoporosis, with an emphasis on increasing ALP levels. This method employed a literature search by collecting several scientific articles discussing the anti-osteoporosis activity of traditional medicinal plants through in vitro, in vivo, and clinical observation studies. The results obtained show that traditional medicinal plants such as Turmeric (Curcuma longa), Black pepper (Piper nigrum), Bromelain (Ananas comosus), Papaya (Carica papaya), Japanese knotweed (Reynoutria japonica Houtt.), Veratrum nigrum, Sickle senna (Cassia tora), Red ginger (Zingiber officinale var. rubrum), Clove (Syzygium aromaticum L.), White turmeric (Curcuma zeadoaria), and Celery (Apium graveolens) are capable of reducing the number of osteoclasts and promoting bone formation. These findings consistently demonstrate a positive role in bone health through increased ALP levels. Indonesian traditional medicinal plants hold great potential as evidence-based anti-osteoporosis agents, particularly through enhancing ALP levels and osteoblast activity. This literature review supports the development of local herbal therapy as a promotive and preventive alternative against osteoporosis.

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References

Adnyana, I. K. (2021). Strategi pengembangan obat herbal di Indonesia. Jakarta: Badan Litbangkes Kemenkes RI.

Ahmad, A., et al. (2022). Efek ekstrak seledri terhadap parameter tulang pada model tikus osteoporosis. Jurnal Fitofarmaka Indonesia, 13(2), 123–129.

Cahyaningsih, E., Pramesthi, F., & Sulistiawati, L. (2022). Review potensi fitoestrogen dalam pencegahan osteoporosis. Jurnal.

Chen, L., Zhang, Y., et al. (2021). Curcumin stimulates osteoblast differentiation through Wnt/β-catenin pathway. Journal of Bone Metabolism, 28(3), 145–152.

Depak, R., Prasad, V., et al. (2020). Piperine inhibits osteoclastogenesis and promotes ALP expression in osteoblasts. Biomedicine & Pharmacotherapy, 128, 110345.

Fitriani, R. (2020). Potensi tanaman obat dalam pengobatan osteoporosis. Jurnal Tradisional dan Fitofarmaka, 5(1), 33–40.

Ismedsyah, R., Wahyuni, T., & Siregar, H. (2023). Aktivitas osteogenik beberapa tanaman obat tradisional Indonesia: Review literatur. Jurnal Biologi Tropis, 23(1), 45–54.

Jiang, H., Zhang, X., et al. (2023). Role of phytoestrogens in bone remodeling: Focus on the RANKL/OPG pathway. Frontiers in Endocrinology, 14, 1123456.

Kim, H. J., et al. (2023). Papain reduces inflammation and enhances ALP levels in bone cells. International Journal of Molecular Sciences, 24(2), 2334.

Kim, S. Y., Lee, M. Y., et al. (2022). Papain increases bone formation markers in osteoporotic rats. Molecules, 27(4), 1123.

Maria, L., Santoso, H., & Putri, D. (2021). Aktivitas cengkeh terhadap kesehatan tulang pada model tikus post-menopause. Jurnal Farmasi dan Ilmu Kesehatan, 11(1), 56–62.

Ningsih, S., Hidayat, R., & Rahmawati, D. (2022). Efek jahe merah terhadap penurunan asam urat dan kesehatan tulang. Jurnal Kesehatan Tradisional, 14(3), 87–94.

Okkay, A., et al. (2022). Bromelain improves ALP activity and bone strength in osteopenic rats. Phytotherapy Research, 36(7), 3545–3552.

Pratiwi, N., et al. (2021). Review peran tanaman herbal lokal dalam pencegahan osteoporosis. Jurnal Kesehatan Masyarakat, 19(2), 98–104.

Sept, A. (2020). Kunyit putih sebagai agen anti inflamasi dalam terapi osteoporosis. Jurnal Herbal Nusantara, 8(4), 203–210.

Suprapto, H., & Amalia, R. (2022). Jamu dan fitoterapi dalam konteks evidence-based medicine. Jakarta: Balai Besar Penelitian dan Pengembangan Tanaman Obat dan Obat Tradisional.

Wang, X., Liu, Y., et al. (2022). Interpretation of elevated ALP in bone diseases. Bone Reports, 17, 101526.

Wicakson, D., & Maulana, R. (2020). Efek ekstrak kecipir terhadap kadar ALP. Jurnal Sains dan Teknologi Farmasi, 10(2), 67–73.

Zhang, L., Zhao, M., et al. (2021). Natural compounds that promote osteoblast ALP expression: A comprehensive review. Journal of Natural Ilmu Kefarmasian Indonesia, 20(1), 1–10.

Zhao, Y., Chen, F., et al. (2023). Evaluation of various herbal extracts on bone metabolism in osteoporosis models. Evidence-Based Complementary and Alternative Medicine, 2023, Article ID 1234567.