Uji Antioksidan Batang Waltheria Indica pada Kondisi Minimal di Daerah Gambut
DOI:
https://doi.org/10.61132/obat.v2i2.620Keywords:
Antioksidant, Gambut, Waltheria IndicaAbstract
Free radicals are unpaired electron molecules that are unstable and can attack important macromolecules causing cell damage in the body. Antioxidants themselves are compounds that can prevent oxidative reactions by free radicals. One of the plants that has the potential as an antioxidant is Walther indica. This study aims to determine the antioxidant activity and determine the total flavonoid content of Waltheria indica stem extract. The method used in this study is the DPPH method which is used to determine antioxidant activity. The antioxidant activity of the Waltheria indica ethanol extract was obtained with an IC50 value of 148.7116 ± 2.061 with a moderate antioxidant category.
Downloads
References
Adiatmika, I. P. G., & Tirtayasa, I. K. (2020). Pemberian ekstrak etanol kubis ungu (Brassica oleracea var. capitata L.) menyebabkan kadar malondialdehid menjadi rendah dan kadar superoksida dismutase menjadi tinggi pada tikus galur Wistar jantan (Rattus norvegicus) yang diberi latihan fisik maksimal. Jurnal Ilmiah Medicamento, 6(2).
Ahmed, I. A., Mikail, M. A., Bin Ibrahim, M., Bin Hazali, N., Rasad, M. S. B. A., Ghani, R. A., Wahab, R. A., Arief, S. J., & Yahya, M. N. A. (2015). Antioxidant activity and phenolic profile of various morphological parts of underutilised Baccaurea angulata fruit. Food Chemistry, 172, 778–787. https://doi.org/10.1016/j.foodchem.2014.09.122
Avoseh, O. N., Ogunwande, I. A., Lawal, O. A., Atabo, J., Ascrizzi, R., & Guido, F. (2019). Anti-inflammatory and anti-nociceptive activities of essential oil of Waltheria indica. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 18(6).
Bakoma, B. (2015). Phytochemical screening, antioxidant and hypoglycemic activity of Coccoloba uvifera leaves and Waltheria indica roots extracts. International Journal of Pharmacy and Pharmaceutical Sciences, 7.
Barnes, G. D. (2020). Combining antiplatelet and anticoagulant therapy in cardiovascular disease. Hematology: American Society of Hematology Education Program, 2020(1), 642–648. https://doi.org/10.1182/hematology.2020000151
Fauziah, Maghfirah, L., & Hardiana. (2021). Gambaran penggunaan obat tradisional pada masyarakat Desa Pulo secara swamedikasi. Jurnal Sains dan Kesehatan Darussalam. https://api.semanticscholar.org/CorpusID:267946544
Laczko, R., Chang, A., Watanabe, L., Petelo, M., Kahaleua, K., Bingham, J.-P., & Csiszar, K. (2020). Anti-inflammatory activities of Waltheria indica extracts by modulating expression of IL-1B, TNF-α, TNFRII and NF-κB in human macrophages. Inflammopharmacology, 28(2), 525–540. https://doi.org/10.1007/s10787-019-00658-6
Liu, F., O’Donnell, T. J., Park, E.-J., Kovacs, S., Nakamura, K., Dave, A., Luo, Y., Sun, R., Wall, M., Wongwiwatthananukit, S., Silva, D. K., Williams, P. G., Pezzuto, J. M., & Chang, L. C. (2023). Anti-inflammatory quinoline alkaloids from the roots of Waltheria indica. Journal of Natural Products, 86(2), 276–289. https://doi.org/10.1021/acs.jnatprod.2c00861
Mira, A., Alkhiary, W., & Shimizu, K. (2017). Antiplatelet and anticoagulant activities of Angelica shikokiana extract and its isolated compounds. Clinical and Applied Thrombosis/Hemostasis: Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 23(1), 91–99. https://doi.org/10.1177/1076029615595879
Nirmala, C., & Sridevi, M. (2021). Ethnobotanical, phytochemistry, and pharmacological property of Waltheria indica Linn. Future Journal of Pharmaceutical Sciences, 7(1), 14. https://doi.org/10.1186/s43094-020-00174-3
P, V., & Alagumanivasagam, G. (2016). In-vitro antioxidant activities of ethanolic extract of whole plant of Waltheria indica (Linn.). International Journal of Pharmacy and Pharmaceutical Sciences, 8, 299–302.
Rao, Y. K., Fang, S.-H., & Tzeng, Y.-M. (2005). Inhibitory effects of the flavonoids isolated from Waltheria indica on the production of NO, TNF-alpha and IL-12 in activated macrophages. Biological & Pharmaceutical Bulletin, 28(5), 912–915. https://doi.org/10.1248/bpb.28.912
Subramani, B., & Sathiyarajeswaran, P. (2022). Current update on herbal sources of antithrombotic activity—a comprehensive review. The Egyptian Journal of Internal Medicine, 34(1), 26. https://doi.org/10.1186/s43162-021-00090-9
Szapáry, L., Tornyos, D., Kupó, P., Lukács, R., El Alaoui El Abdallaoui, O., & Komócsi, A. (2022). Combination of antiplatelet and anticoagulant therapy, component network meta-analysis of randomized controlled trials. Frontiers in Cardiovascular Medicine, 9, 1036609. https://doi.org/10.3389/fcvm.2022.1036609
Tampubolon, L., Ginting, A., & Turnip, F. (2023). Gambaran faktor yang mempengaruhi kejadian penyakit jantung koroner (PJK) di Pusat Jantung Terpadu (PJT). Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal, 13, 1043–1052. https://doi.org/10.32583/pskm.v13i3.1077
Tangkery, R. A. B., Paransa, D. S., & Rumengan, A. (2013). Uji aktivitas antikoagulan ekstrak mangrove Aegiceras corniculatum. Jurnal Pesisir dan Laut Tropis, 1(1). https://doi.org/10.35800/jplt.1.1.2013.1278
Termer, M., Carola, C., Salazar, A., Keck, C. M., Hemberger, J., & von Hagen, J. (2021). Identification of plant metabolite classes from Waltheria indica L. extracts regulating inflammatory immune responses via COX-2 inhibition. Journal of Ethnopharmacology, 270, 113741. https://doi.org/10.1016/j.jep.2020.113741
Yougbaré-Ziébrou, M. N., Marius, L., Noufou, O., Yaro, B., & Guissoun, I. (2016). Antioxidant, analgesic and anti-inflammatory activities of the leafy stems of Waltheria indica L. (Sterculiaceae). Journal of Applied Pharmaceutical Science, 6, 124–129. https://doi.org/10.7324/JAPS.2016.60219
Zaragozá, C., Álvarez-Mon, M. Á., Zaragozá, F., & Villaescusa, L. (2022). Flavonoids: Antiplatelet effect as inhibitors of COX-1. Molecules, 27(3). https://doi.org/10.3390/molecules27031146
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.