Uji Efek Antihiperglikemik Seduhan Daun Sirih Cina (Peperomia Pellicida) Diberikan Secara Oral Pada Mencit Jantan (Mus Musculus)

Ruri Ayu Agrace; Riana Versita; Muhamad Arifin; Dwi Kurnia Putri; Dwi Dominica; Dian Handayani; Ikhsan Ikhsan

doi:10.61132/obat.v2i3.401

Authors

Ruri Ayu Agrace Universitas Bengkulu
Riana Versita Universitas Bengkulu
Muhamad Arifin Universitas Bengkulu
Dwi Kurnia Putri Universitas Bengkulu
Dwi Dominica Universitas Bengkulu
Dian Handayani Universitas Bengkulu
Ikhsan Ikhsan Universitas Bengkulu

DOI:

https://doi.org/10.61132/obat.v2i3.401

Keywords:

Paperomia pellucida, Glibenclamide, Antihyperglycemic

Abstract

Chinese Betel Plant (Paperomia pellucida) is an herbal plant that has benefits for treating diseases such as acne, ulcers, antidiabetic, antioxidant, anti-inflammatory, antimicrobial, and antibacterial. The content of bioactive compounds from Chinese betel include alkaloids, flavonoids, steroids, saponins, tannins, triterpenoids, and carbohydrates. The aim The purpose of this study was to determine the effect of steeping Chinese betel and on reducing blood glucose levels in male mice. This method used is an experimental method at the Pharmacology Laboratory D3 Pharmacy FMIPA Bengkulu University. The test animals used were three groups, namely the positive control treatment group that received glibenclamide, the negative control treatment group received aquadest, and the 2% Chinese betel steeping treatment group. The results showed that Chinese betel curd was reduced from 125 mg/dl to 93 mg/dl and there was no hypoglycemic decrease in blood glucose due to glibenclamide. From the results of the study it can be concluded that the administration of Chinese betel and glibenclamide steeping is effective in lowering blood glucose levels in male mice.

References

Hamzah, R. U., Odetola, A. A., Erukainure, O. L., & Oyagbemi, A. A. (2012). Peperomia pellucida in diets modulates hyperglyceamia, oxidative stress and dyslipidemia in diabetic rats. Journal of Acute Disease, 1.

Katzung, B. G. (2004). Farmakologi Dasar dan Klinik. Edisi XIII. Buku 3. Translated by Bagian Farmakologi Fakultas Kedokteran Universitas Airlangga. Jakarta: Salemba Medika.

Kusumawarni, P., Supriyatna, & Susilawati, Y. (2012). Aktivitas Antidiabetes Fraksi Etil Asetat dari Herba Sasaladaan (Peperomia pellucida (L.) Kunth.) dengan Metode Induksi Aloksan. Students E-Journals, 1(1).

Majumder, P. (2011). Phytochemical Pharmacognostical And Physicochemical Standardization Of Peperomia Pellucida L. HBK. Stem Pharmacie Globale International Journal Of Comprehensive Pharmacy, 8(06).

Perkeni. (2015). Konsensus Pengelolaan dan Pencegahaan Diabetes Melitus Tipe 2 di Indonesia. Jakarta.

Pradhan, D., Suri, K. A., Pradhan, D. K., & Biswasror, P. (2013). Golden heart of nature Piper betle Linn. Journal of Pharmacognosy and Phytochemistry, 1(6), 147–167.

Salempa, P. (2016). Uji Bioaktivitas Senyawa Metabolit Sekunder Ekstrak Kloroform Kulit Batang Sirsak (Annona muricata Linn). Jurnal Bionature, 17(1), 37–40.

Sangeetha, S. K., Umamaheswari, S., Reddy, M., & Kalkura, N. S. (2016). Flavonoids : Therapeutic Potential of Natural Pharmacological Agents. International Journal of Pharmaceutical Sciences Research, 7, 3924–3930.

Saputra, D. A. (2014). Uji Toksisitas Ekstrak Etanol Daun Suruhan (Peperomia pellucida L. Kunth) dengan Metode BST (Brine Shrimp Lethality Test). Makasar: UIN Alauddin Makasar.

Tjandrawinata, R. R. (2016). Patogenesis Diabetes Tipe 2 : Resistensi Defisiensi Insulin. Dexa Laboratories of Biomolecular Science, 1–4.

Tjay, T. H., & Rahardja, K. (2007). Obat-Obat Penting Khasiat, Penggunaan dan Efek-Efek Sampingya. Jakarta: PT. Elex Media Komputindo.

Tukayo., Brechkerts, L. A., Debyjen, R. T., & Marselino, F. P. (2018). Rebusan Daun Kersen (Muntingia calabura L.) Menurunkan Glukosa Darah pada Kelinci (Oryctolagus cuniculus). Gema Kesehatan, 10(1).