Daun Sirih Hutan (Piper Aduncum) Terhadap Penghambatan  Transport Glukosa Menggunakan Ileum Tikus Putih  (Rattus Novergicus) dengan Metode Infusa

Haryanto Haryanto; Febriyanti Aswinda

doi:10.61132/obat.v3i2.1161

Authors

Haryanto Haryanto Universitas Muhammadiyah Makassar
Febriyanti Aswinda Universitas Muhammadiyah Makassar

DOI:

https://doi.org/10.61132/obat.v3i2.1161

Keywords:

Diabetes Mellitus, Wild Betel Leaves, White Rats, Infusion Method.

Abstract

Diabetes mellitus is one of the chronic diseases whose prevalence is increasing worldwide. This disease is characterized by high blood glucose levels due to impaired insulin production or function, the hormone that regulates blood sugar levels. This study aims to examine the effect of wild betel leaf extract (Piper aduncum) on the inhibition of glucose transport using the ileum of white rats (Rattus norvegicus) with the infusion method. This research is a pre-experimental study with a posttest-only control design using white rats and wild betel leaves. The study demonstrates that wild betel leaves (Piper aduncum L.) and red betel leaves (Piper crocatum) have significant potential in inhibiting glucose transport and reducing blood sugar levels. This is evident from the significant decrease in the rate of glucose transport after the administration of wild betel leaf extract, indicating an inhibitory effect on glucose transporters such as SGLT-1 and GLUT-2.

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