Efektivitas Bahan Alami dalam Meningkatkan Jumlah Sel Fibroblas pada Soket Gigi Tikus Wistar Setelah Pencabutan Gigi

Muhammad Fajrin Wijaya; Aditya H. Asmara; Indrya Kirana Mattulada; Andy Fairuz Zuraida Eva; Andi Fajrin Perdana Sam

doi:10.61132/corona.v3i1.1079

Authors

Muhammad Fajrin Wijaya Universitas Muslim Indonesia, Makassar
Aditya H. Asmara Universitas Muslim Indonesia, Makassar
Indrya Kirana Mattulada Universitas Muslim Indonesia, Makassar
Andy Fairuz Zuraida Eva Universitas Muslim Indonesia, Makassar
Andi Fajrin Perdana Sam Universitas Muslim Indonesia, Makassar

DOI:

https://doi.org/10.61132/corona.v3i1.1079

Keywords:

Natural Substances, Fibroblasts, Dental Sockets, Wistar Rats, Tooth Extraction

Abstract

The healing process of a tooth socket after extraction involves various stages, including the proliferation of fibroblasts that play a role in the formation of new tissue. Natural ingredients have long been used in accelerating wound healing, but their effectiveness in increasing the number of fibroblast cells still needs to be studied further. To determine the effectiveness of natural ingredients in increasing the number of fibroblast cells in the tooth socket of Wistar rats after tooth extraction. Methods: This is a literature review that collects and analyzes scientific articles from various databases such as PubMed, Google Scholar, DOAJ, Garuda Portal, and CrossRef. The selected articles met the predetermined inclusion criteria, including studies conducted on Wistar rats and using natural ingredients as interventions. Red ginger extract at 10% concentration was found to be the most effective ingredient in increasing the number of fibroblasts and accelerating wound healing. Red ginger extract (Zingiber officinale var. rubrum) is the most effective natural ingredient in increasing the number of fibroblast cells in the tooth socket of Wistar rats after tooth extraction.

Downloads

Download data is not yet available.

References

’Rahma, O. S., ’MA’ruf, T. M., & “Setiawan. (2019). Pengaruh Gel Ekstrak Kulit Buah Jengkol (Pithecellobium Lobatum Benth) Terhadap Jumlah Sel Fibroblas Pada Luka Insisi Tikus Wistar. Proceeding Book , 2(1), 179–185.

Atmajaya, S., Satrya, D. S., Kathiningsih, R., & Rizqiawan, A. (2019). Snakehead fish extract (Channa Striata) increase the number of fibroblasts cells post extraction tooth in wistar rats (Rattus Norvegiccus). Biochemical and Cellular Archives, 19(2), 4863–4866. https://doi.org/10.35124/bca.2019.19.S2.4863

Aulia Rahmawati, A., Harijadi, A. ., Kristanto, Y. ., & Asmarani, Y. K. . (2023). Pengaruh Gel Ekstrak Bawang Merah terhadap Jumlah Fibroblas pada Luka Ekstraksi Gigi Tikus Jantan Wistar. Bhakta Dental Journal, 1(2), 1–7. https://bdj.iik.ac.id/index.php/bdj/article/view/17

Eni, N., & Asridiana, A. (2020). Prevalensi Pencabutan Gigi Permanen Di Poliklinik Gigi Puskesmas Kaluku Bodoa Di Kota Makassar. Media Kesehatan Gigi : Politeknik Kesehatan Makassar, 19(1). https://doi.org/10.32382/mkg.v19i1.1596

Florenly. (2022). Manfaat Ekstrak Etanol Kunyit dalam Penyembuhan Luka Paska Ekstraksi Gigi. Publish Buku UNPRI Press Isbn. https://jurnal.unprimdn.ac.id/index.php/ISBN/article/view/2288

Herdiani, M., Pramasari, C. N., & Purnamasari, C. B. (2022). Pengaruh ekstrak daun kelor (Moringa oleifera Lam.) terhadap penyembuhan luka. Mulawarman Dental Journal, 2(1), 16-29. http://dx.doi.org/10.30872/mul.%20dent.%20j.v2i1.5533

Himammi, A. N., & Hartono, B. T. (2021). Ekstraksi Gigi Posterior dengan Kondisi Periodontitis Kronis Sebagai Persiapan Pembuatan Gigi Tiruan Lengkap pada Pasien Diabetes Mellitus. Jurnal Kesehatan Gigi, 8(1), 6–10. https://doi.org/10.31983/jkg.v8i1.6572

Jannah Tamara, A. H., Rochmah, Y. S., & Mujayanto, R. (2015). Pengaruh Aplikasi Virgin Coconut Oil Terhadap Peningkatan Jumlah Fibroblas Pada Luka Pasca Pencabutan Gigi Pada Rattus Novergicus. Odonto : Dental Journal, 1(2), 29. https://doi.org/10.30659/odj.1.2.29-34

Karini, N. D. (2024). Pengaruh Nanoemulgel Jintan Hitam (Nigella Sativa) Terhadap Jumlah Fibroblas Dalam Penyembuhan Luka Pasca Pencabutan Gigi Pada Tikus. Jurnal Medali, 6(1), 43. https://doi.org/10.30659/medali.6.1.43-51

Khoswanto, C., Juliastuti, W. S., & Adla, K. A. (2018). The effect of Avocado leaf extract (Persea americana Mill.) on the fibroblast cells of post-extraction dental sockets in Wistar rats. Dental Journal, 51(3), 129–132. https://doi.org/10.20473/j.djmkg.v51.i3.p129-132

Kurnia, A. P., Ardhiyanto, B. H., & Suhartini. (2015). Potensi Ekstrak Teh Hijau (Camellia sinensis) Terhadap Peningkatan Jumlah Sel Fibroblas Soket Pasca Pencabutan Gigi pada Tikus Wistar. e-Jurnal Pustaka Kesehatan, 3(1), 122–127. http://repository.unej.ac.id/handle/123456789/58559

Kurniawati, A., Kristanti, Y. D., Rahmat, N. A., Rahayu, Y. C., Cholid, Z., & Sosiawan, A. (2024). The role of purple leaves extract (Graptophyllum Pictum (L.) Griff) on the number of fibroblasts and blood vessels in the socket after tooth extraction. Dental Journal, 57(1), 56–61. https://doi.org/10.20473/j.djmkg.v57.i1.p56-61

Kusumastuti, E., & Deno, R. (2020). Pengaruh Ekstrak Kembang Sepatu (Hibiscus Rosa-SinensisL.) terhadap Jumlah Sel fibroblast dan Angiogenesis pada Penyembuhan Luka Pencabutan Gigi Tikus Putih (RattusNorvegicus). Jurnal Wiyata: Penelitian Sains dan Kesehatan, 7(1), 1-12. http://dx.doi.org/10.56710/wiyata.v7i1.308

Lande, R., Kepel, B. J., & Siagian, K. V. (2015). Gambaran Faktor Risiko Dan Komplikasi Pencabutan Gigi Di RSGM PSPDG-FK Unsrat. E-Gigi, 3(2). https://doi.org/10.35790/eg.3.2.2015.10012

Lestari, N., Mattalitti, S. F. O., Bima, L., Wijaya, M. F., & Adinda, T. (2022). Efektivitas Ekstrak Daun Cocor Bebek (Kalanchoe pinnata) Terhadap Peningkatan Jumlah Sel Fibroblas Soket Paska Pencabutan Gigi Tikus Wistar. Sinnun Maxillofacial Journal, 4(02), 94–103. https://doi.org/10.33096/smj.v4i02.86

Liestia, B. layla, Prasetyarini, S., & Indriana, T. (2020). Potensi Ikan Teri (Stolephorus Sp) Terhadap Peningkatanjumlah Sel Fibroblas Pada Soket Pasca Pencabutan Gigi. Makassar Dental Journal, 9(1), 44–47. http://dx.doi.org/10.30659/odj.9.1.40-45

Luthfi, M., Juliastuti, W. S., Risky, Y. A., Wijayanti, E. H., Rachmawati, A. E., & Asyhari, N. P. O. (2020). Expression of Fibroblast Cells after Extraction of Wistar Rat Teeth after Topical Application of Okra Fruit (Abelmoschus esculentus) Gel. Infectious Disease Reports, 12(11), 8726. https://doi.org/10.4081/idr.2020.8726

Mardiyantoro, F., Fidya, F., & Andriani, D. S. (2019). Pengaruh Gelatin Ikan Patin (Pangasius Djambal) Terhadap Jumlah Fibroblas Pada Luka Pasca Pencabutan Gigi Tikus Putih (Rattus Norvegicus). ODONTO : Dental Journal, 6(1), 1. https://doi.org/10.30659/odj.6.1.1-5

Oroh, C. G., Pangemanan, D. H. C., & Mintjelungan, C. N. (2015). Efektivitas Lendir Bekicot (Achatina Fulica) Terhadap Jumlah Sel Fibroblas Pada Luka Pasca Pencabutan Gigi Tikus Wistar. E-Gigi, 3(2). https://doi.org/10.35790/eg.3.2.2015.10325

Rinaldi, D. H., Kamadjaja, D. B., & Sumarta, N. P. M. (2018). The effects of breadfruit leaf (Artocarpus Altilis) extract on fibroblast proliferation in the tooth extraction sockets of Wistar rat. Dental Journal, 51(3), 143–146. https://doi.org/10.20473/j.djmkg.v51.i3.p143-146

Sim, M., Lokanata, S., Anggie Adrisya Lubis, P., Nurul Rian Ananda, T., Paradita Dalimunthe, R., Suryantika. (2022). Efektivitas ekstrak jahe merah (Zingiber officinale var. Rubrum) terhadap pembentukan sel fibroblas soket gigi tikus wistar. Prima Journal of Oral and Dental Sciences, 5(1), 1–6. https://doi.org/10.34012/primajods.v5i1.2400

Sorongan, S. R., Pangemanan, & ’Siagian, K. (2015). Efektivitas Perasan Daun Pepaya Terhadap Aktivitas Fibroblas Pasca Pencabutan Gigi Pada Tikus Wistar Jantan. PHARMACON Jurnal Ilmiah Farmasi, 4(4), 52–57. https://doi.org/10.35799/pha.4.2015.10192

Tiarasanti, F., Sufiawati, I., Amalia, E., Sari, K., Zubaedah, C., & Takarini, V. (2024). The Effects of Potato (Solanum tuberosum L. vs. Granola; Solanaceae) Peel Extract Gel on Gingival Wound Healing in Wistar Rats. Journal of Experimental Pharmacology, Volume 16, 25–35. https://doi.org/10.2147/jep.s443355